Various techniques for preparation of nanosuspension a. Nowadays, a very large proportion of new drug candidates emerging from drug discovery programmes are water insoluble and thus poorly bioavailable. An increasing amount of amorphous drug fraction could induce higher saturation solubility. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Nanosuspension enhance bioavailability 15 drug with poor solubility, poor permeability or poor solubility in gastrointestinal tract will leads to poor oral bioavailability.
Nanosuspension technology can be used to improve the stability as well as bioavailability of poorly soluble drug. Nanosuspension a novel approaches in drug delivery system chaudhari shilpa p, kamble. Nanosuspension a novel approaches in drug delivery system. In case of drugs that are insoluble in both water and in organic media instead of using lipidic systems, nanosuspensions are used as a formulation approach. The objective of the study was to assess the effect of surfactants and polymers on particle size and drug release.
Kulkarni abstract nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma pc3 cell line. Increasing possibilities of nanosuspension hindawi. Chabot, demonstrated that nanoemulsion formulation of fisetin improves its bioavailability and antitumour activity in mice 49. Investigation of a nanosuspension stabilized by soluplus. Summary of nanosuspension formation technologies and compounds produced in nanosuspension. The aim of the present study was to enhance the pharmaceutical potential and oral bioavailability of piperine, which is the bioactive constituent of piper nigrum, using the nanosuspension approach. A high pressure homogenization technique was used to produce nanosuspensions. Solidification of nanosuspension via spray granulation yidan lan1, srikanth kakumanu2, carl beckett2, nigel langley1 1 basf corporation, pharma ingredients and services, 500 white plains road, ny 10591 2 covaris incorporated, 14 gill street, woburn, ma 01801 yidan. Fifteen formulations were prepared by the use of different combinations of. Nanosuspension consists of the pure poorly watersoluble drug without any matrix material suspended in dispersion. Dissolution enhancement of nifedipine by preparing drug nanosuspensions using media milling technique 5. Pdf increasing possibilities of nanosuspension kumar. The present work is aimed at the formulation and evaluation of nanosuspension of felodipine, a poorly water soluble antihypertensive drug.
Review article nanosuspension drug delivery 1jain amit k. Currently more than 40% of new chemical entities are reported to be lipophilic compounds and onethird of drugs recognized by united states pharmacopeia are poorly soluble chen et al. Formulation and characterization of itraconazole oral nanosuspension. Thus, improving oral bioavailability of olm can increase clinical efficacy. In another study, the particle size of resveratrol nanosuspension was increased by increasing the amount of the drug and concentration of the stabilizer. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and h96 approach and to evaluate the effectiveness of h96 approach. Nanosuspension a pharmaceutical nanosuspension is defined as very finely dispersed solid drug particles in an aqueous or organic vehicle for either oral and topical use or parenteral and pulmonary administration.
Development and characterization of nanosuspensions of. Formulations were designed based on full factorial design. Patel pharmacy college, linch, mehsana, gujarat, india 2nootan pharmacy college, visnagar384315, gujarat, india. Increasing possibilities of nanosuspension mafiadoc. Nanosuspension have emerged as a promising strategy for the efficient delivery of hydrophobic drugs. A nanosuspension is a submicron colloidal dispersion of drug particles. Pharmapharmaceutics iii sem amity institute of pharmacy 2. A nanosuspension not only solves the problem of poor solubility and bioavailability but also alters the pharmacokinetics of drug and that improves drug safety and e cacy. Kumar bishwajit sutradhar, sabera khatun, and irin parven luna. Nanosuspension consist of the poorly water soluble compound without any matrix material suspended in dispersion. Pdf increasing possibilities of nanosuspension sabera. Csa nanosuspension was prepared by high pressure homogenization technology.
However, the most attractive option for increasing the release rate is improvement of the solubility through formulation. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve. Review article increasing possibilities of nanosuspension. Agglomeration, nanosuspension, ostwald ripening, stability issues, stability of nanosuspension, steric stabilization.
Nanosuspension international journal of pharmaceutical sciences. Arshad ahmed khan department of pharmaceutics, raghavendra institute of pharmaceutical education and research, anantapuramu515721, andhra pradesh, india. Increasing possibilities of nanosuspension by kumar bishwajit sutradhar, sabera khatun and irin parven luna no static citation data no static citation data cite. Increasing possibilities of nanosuspension kumar bishwajit sutradhar, sabera khatun, and irin parven luna depar tment of pharmac y, stamford university bangl adesh, 51 siddeswari road, dhaka 1. Nanosuspension formulation approach is most suitable for the compounds with high log p value, high melting point and high dose. Preparation of nanosuspension is simple and applicable to. Introduction 3 nanosuspension can be defined as a biphasic system consisting of pure drug particles dispersed in a aqueous vehicle in which the diameter of the suspended particle is less than 1. The nanosuspensions were subjected to evaluations involving particle size, dissolution. Methyl cellulose as promising stabilizer nehal daebis 1, ossama y abdallah2, magda elmassik, and hamdy abdelkader3 1department of pharmaceutics, faculty of pharmacy and drug manufacturing, pharos university, alexandria, egypt. Potential benefits of nanosuspension technology for.
Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. Formulation and optimization of nanosuspensions for enhancing simvastatin dissolution using central composite design vikram m. Nanosuspension has shown to have greater drug loading compared to other oral dosage form, and thus, lower dose is required to achieve intended therapeutic effect and patient compliance can be improved with the use of this drug delivery system yadav and singh, 2012. Nanosuspension free download as powerpoint presentation. In recent years nanoemulsion has become a promising tool to improve bioavailability of several drugs along with nanosuspension and other various solubility enhancement techniques 61. Nowadays, nanosuspension is a growing approach for pharmaceutical product development due to several unique properties applicable in pharmaceutical field. Review article increasing possibilities of nanosuspension kumar bishwajit sutradhar, sabera khatun, and irin parven luna department of pharmacy, stamford university bangladesh, 51 siddeswari road, dhaka 1217, bangladesh correspondence should be addressed to kumar bishwajit sutradhar. Furthermore, an increase in particle size and pdi by increasing the concentration of the stabilizer may result from ostwald ripening.
Formulation as nanosuspension is an attractive and promising alternative to solve these problems. The interest in the preparation and application of nanometersized materials is increasing due to their tremendous potential as a drug delivery system with wide range of applications. Figure 3 increasing possibilities of nanosuspension. During the process of drug exploration and investigation, more and more new drug candidates have been found to be insoluble or poorly soluble in aqueous medium or organic solvent grau et. Nanosuspension for enhancement of oral bioavailability of. Nanosuspension resolves the problem of poor bioavailability by solving the problem of. Nanosuspension for enhancement of oral bioavailability of felodipine. Solubility is the crucial factor for drug effectiveness, independence of the route of administration.
The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin a. Increasing possibilities of nanosuspension open access. Nanosuspensions are colloidal dispersions of nanosized drug particles stabilized by surfactants. Sparfloxacin ons were prepared by optimizing the concentration of hpmc e5 and water soluble chitosan by using solvent diffusion method followed by. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve the solubility problems. Schematic diagram of preparation methods of nanosuspension. In nanosuspension technology, the drug is maintained in the required crystalline state with reduced particle size, leading to an increased dissolution rate and therefore improved bioavailability. Preparation and characterization of nanosuspension of. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort. Zeta potential of the optimized formulation was measured using the same instrument. Formulation and comparative evaluation of hpmc and water. Nanosuspension has been reported to enhance absorption and bioavailability.
Preparation and evaluation of vitamin a nanosuspension as. The main possibilities for improving dissolution according to this analysis are to increase the surface area available for dissolution by decreasing the particle size of the solid dispersion. Consequently, it can increase saturation solubility determined by. Nanosuspension pharmaceutical formulation solubility. Preparation, characterization and stabilization of. Dissolution enhancement of nifedipine by preparing drug.
Oral drug delivery of nanosuspension with receptor mediated endocytosis has the. Pdf increasing possibilities of nanosuspension researchgate. Nanosuspensions are fine dispersion of uniformsized solid particles in an aqueous vehicle. Increased zeta potential values indicate that the formulation has good. Emerging role of nanosuspensions in drug delivery systems. The reduction of drug particles into the submicron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. Solidification of nanosuspension via spray granulation. Possibilities of increasing coal charge density by adding fuel oil. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of. Lutful amin 1 1 department of pharmacy, stamford university bangladesh, 51, siddeswari road, dhaka1217, bangladesh.
The oral bioavailability of poorly water soluble drug can be improved using nanosuspension. Nanoprecipitation, which is a simple and reproducible process, was used for. The main challenge in nanosuspension technology is prevention of particle agglomeration or aggregation and crystal growth. The homogenized nanosuspension was freeze dried by using virtis freeze dryer for increasing the shelf life of suspension and to study the dissolution behavior. Nanosuspensions are also use in various dosage forms, including specialized drug delivery system such as mucoadhesive hydrogel. Formulation and characterization of itraconazole oral. Nanosuspension has been found to possess great potential to rectify the several. Increasing the amorphous fraction in the particles, leading to a potential change in. Formulation and optimization of nanosuspensions for. A pharmaceutical nanosuspension is defined as very finely colloid, biphasic, dispersed, and solid drug particles in an aqueous vehicle, size below 1. Schematic representation of the media milling process. Employment analysis of the turkish banking sector and possibilities for increasing the employment capacity.
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